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Department : R&D
Reference : PDFMM140317
Date : 17/03/2017
Place : Croissy sur Seine
Fixed 18 months term. The position will be based in Croissy-sur-Seine
In order to successfully meet the challenges presented by molecular modeling, and In line with our ambition of always developing innovation at Servier, we are looking for a post-doctoral fellow to join the team!
As part of the molecular modeling and cheminformatics team (8 colleagues), your mission will consist in designing protein-protein interaction inhibitors, such as peptidomimetics, macrocycles or macrocyclic peptides in collaboration with the chemistry department. You will lead conformational analyses, docking and molecular dynamic simulations in order to study compound stability in their protein target, aiming at prioritizing scaffolds based on their binding interactions. You will as well design scaffold-based libraries while optimizing their molecular diversity.
SKILLS AND EDUCATION LEVEL REQUIRED
• PhD in molecular modeling or structural bioinformatics with very good knowledge of protein-ligand interactions, thermodynamics and kinetics.
• Good knowledge of molecular dynamics methods such as steered-MD, replica exchange and metadynamics.
• Protein-ligand docking, molecular dynamics simulation and analysis and pharmacophore modeling.
• Good skills in library design, molecular diversity analysis and statistical analysis would be much appreciated.
Software skills: Maestro, MOE, LigandScout, Amber, NAMD, GROMACS, VMD and Pipeline Pilot or Knime.
Our working spirit is based on entrepreneurship, collaboration, result orientation and communication.
You can also send a detailed curriculum vitae and covering letter stating your reasons for interest in this position and current salary package to:
Institut de Recherche Servier
Alexandra BERNARD DIJON (réf Qualité)